Polymer based Drug Delivery Systems- benchtop to Bedside Transition

Research in the field of polymers and polymeric materials has garnered immense attention past few decades due to versatile functional structural capabilities which often can be manipulated for applications therapy diagnosis a host diseases disorders. Polymer therapeutics comprises polymer-drug polymer-protein conjugates as well supramolecular systems used drug delivery systems. Although pharmacological industry invests immensely design discovery novel molecules, small molecular drugs are inefficient targeting many like deep seated low vasculature tumours, metastasized cancers various autoimmune diseases. Coupled with rapid clearance rate, solubility, resistance high off target toxicity these present modest benefits common In order improve therapeutic index pre-existing shortening translation from preclinical validation clinical approval, vast area research focuses on improvement carriers by alterations. The major challenges currently faced include payload, transition through desmoplastic barrier solid tumours hepatic renal clearance. address issues numerous polymer–protein have been engineered reported enhance stability pharmacokinetic properties active drugs. Highly toxic anticancer doxorubicin, cis-platin gemcitabine successfully coupled weight formulate targeted agents, some undergone successful trials. Apart PEGylated polymers, dendritic polyplexes DNA or RNA moieties also considered candidates improving Ongoing efforts development polymer-based promising open new horizons personalized medicine effective cure life-threatening